Drug-Drug interactions in opioid therapy 9780955879562

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Titel: Drug-Drug interactions in opioid therapy
Auteur: Professor Elinore McCance-Katz
ISBN: 9780955879562
Conditie: Beetje gebruikt

Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co-occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid-addicted individuals. These clinical realities place patients being treated with methadone and buprenorphine at risk for potentially toxic drug interactions. A substantial literature has accumulated on drug interactions between either methadone or buprenorphine with other medications when ingested concomitantly by humans. This review summarizes current literature in this area.




The World Health Organization reports that drug interactions are a leading cause of morbidity and mortality.This finding extends to medications used in the treatment of substance use disorders and pharmacotherapies utilized for treatment of medical or mental illnesses, as well as for abused substances—including alcohol, licit, and illicit substances. Furthermore, there has been a dramatic increase in deaths related to methadone use, both for the treatment of pain and illicit use, in the United States in recent years. Drug interactions have been implicated in many of these deaths. In this paper, we will review the existing literature on drug interactions principally between opioids used in the treatment of opioid dependence, methadone and buprenorphine, and other medications with a focus on clinically relevant drug interactions in humans. Interactions between cocaine, alcohol, and other substances will also be summarized.

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