Tyranny and Mutation is the second studio album by American hard rock band Blue Öyster Cult, released on February 11, 1973 by Columbia Records. The record was produced by Murray Krugman and Sandy Pearlman. On May 12, 1973, the album peaked at number 122 on the Billboard 200 chart.

The song "Baby Ice Dog" features lyrics by singer/poet Patti Smith (who was keyboardist Allen Lanier's girlfriend at the time), who would make several lyrical contributions to the band's repertoire during its career. The song "The Red and the Black", with lyrics referencing the Royal Canadian Mounted Police, is a renamed, re-recorded version of "I'm on the Lamb but I Ain't No Sheep" from the debut album of the same name. The song was later covered by the Minutemen and Band of Susans.

Tyranny and Mutation is available on black vinyl. 180 gram audiophile vinyl.

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